Ryan Hoiland

Assistant Professor, CCDPM

Centre for Chronic Disease Prevention and Management, Southern Medical Program

Other Titles: Assistant Professor, Department of Cellular & Physiological Sciences, Faculty of Medicine; Affiliate Investigator, Interior Health Authority; Researcher, Vancouver Coastal Health Research Institute; Full Member, Djavad Mowafaghian Centre for Brain Health; Affiliate Investigator, International Collaboration on Repair Discoveries; Michael Smith Health Research BC Scholar.
Email: ryan.hoiland@ubc.ca

Research Summary

To determine neuroprotective strategies to improve outcomes for patients suffering an acute central nervous system injury. We conduct studies across the translational continuum in pre-clinical disease models, healthy human studies, and clinical patient studies to characterize the pathophysiology of acute traumatic and/or ischemic central nervous system injury. This includes a focus on determining how we can optimize oxygen delivery to the brain and spinal cord following an acute injury.

Courses & Teaching

FLEX Student Supervision, MD Undergraduate Program, UBC
Directed Studies Supervisor

Biography

Dr. Hoiland completed his PhD (2015-2018) at the University of British Columbia Okanagan, where he studied cerebrovascular physiology and human adaptation to hypoxia. As a postdoctoral fellow, Dr. Hoiland investigated the pathophysiology of hypoxic-ischemic brain injury as well as traumatic spinal cord injury, with a focus on mitigating secondary hypoxic injury. Collectively, his training involved studying how the central nervous system responds to hypoxia in pre-clinical disease models, healthy humans, and patients.

Degrees

2018 PhD, University of British Columbia
2015 MSc, University of British Columbia

Selected Publications & Presentations

Hoiland RL, Robba C, Menon DK, Citerio G, Sandroni C, Sekhon MS. Clinical targeting of the cerebral oxygen cascade to improve brain oxygenation in patients with hypoxic-ischaemic brain injury after cardiac arrest. Intensive Care Med. 2023 Sep;49(9):1062-1078. doi: 10.1007/s00134-023-07165-x. PMID: 37507572

Hoiland RL, MacLeod DB, Stacey BS, Caldwell HG, Howe CA, Nowak-Flück D, Carr JM, Tymko MM, Coombs GB, Patrician A, Tremblay JC, Van Mierlo M, Gasho C, Stembridge M, Sekhon MS, Bailey DM, Ainslie PN. Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and S-nitrosothiol mediated signal transduction. J Cereb Blood Flow Metab. 2023 Sep;43(9):1519-1531. doi: 10.1177/0271678X231169579. PMID: 37042194

Hoiland RL, Rikhraj KJK, Thiara S, Fordyce C, Kramer AH, Skrifvars MB, Wellington CL, Griesdale DE, Fergusson NA, Sekhon MS. Neurologic Prognostication After Cardiac Arrest Using Brain Biomarkers: A Systematic Review and Meta-analysis. JAMA Neurol. 2022 Apr 1;79(4):390-398. doi: 10.1001/jamaneurol.2021.5598. PMID: 35226054.

Hoiland RL, Caldwell HG, Carr JMJR, Howe CA, Stacey BS, Dawkins T, Wakeham DJ, Tremblay JC, Tymko MM, Patrician A, Smith KJ, Sekhon MS, MacLeod DB, Green DJ, Bailey DM, Ainslie PN. Nitric oxide contributes to cerebrovascular shear-mediated dilatation but not steady-state cerebrovascular reactivity to carbon dioxide. J Physiol. 2022 Mar;600(6):1385-1403. doi: 10.1113/JP282427. PMID: 34904229.

Hoiland RL, Ainslie PN, Wellington CL, Cooper J, Stukas S, Thiara S, Foster D, Fergusson NA, Conway EM, Menon DK, Gooderham P, Hirsch-Reinshagen V, Griesdale DE, Sekhon MS. Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest. Circ Res. 2021 Aug 20;129(5):583-597. doi: 10.1161/CIRCRESAHA.121.319157. PMID: 34287000.

Further publications can be found here.

Selected Grants & Awards

Brain Canada Future Leaders in Canadian Brain Research (2024-2026)
Michael Smith Health Research BC Scholar Program Award (2023-2028)

Professional Services/Affiliations/Committees

Steering Committee Member – Cerebrovascular Research Network (CARNet)
Reviewing Editor – Experimental Physiology